![]() Alzheimer’s disease (AD) and behavioral variant frontotemporal dementia (bvFTD) are among the most prevalent neurodegenerative diseases, each linked to specific pathophysiology and to highly heterogeneous and atypical manifestation, hindering detection and diagnosis ( Musa et al., 2020 Parra et al., 2018). ![]() Neurodegenerative diseases and dementia represent an increasing social and economic burden to worldwide health ( GBD 2019 Dementia Forecasting Collaborators, 2022), with rising prevalence and incidence in countries with an aging population and specially across underrepresented populations from the developing world, where classical biomarkers and treatments are not yet massively available ( Hou et al., 2019 Mukadam et al., 2019 Parra et al., 2018 Parra et al., 2023). Overall, we obtained novel insights on disease progression and control by means of external stimulation, while identifying dynamical mechanisms that underlie functional alterations in neurodegeneration. Finally, we perturbed the model to reveal key AD- and bvFTD-specific regions to induce transitions from pathological to healthy brain states. Using variational autoencoders, we visualized different pathologies and their severity as the evolution of trajectories in a low-dimensional latent space. These models included disease-specific atrophy maps as priors to modulate local parameters, revealing increased stability of hippocampal and insular dynamics as signatures of brain atrophy in AD and bvFTD, respectively. To address this problem, we combined deep learning with a model capable of reproducing whole-brain functional connectivity in patients diagnosed with Alzheimer’s disease (AD) and behavioral variant frontotemporal dementia (bvFTD). The treatment of neurodegenerative diseases is hindered by lack of interventions capable of steering multimodal whole-brain dynamics towards patterns indicative of preserved brain health. Trinity College Institute of Neuroscience (TCIN), Trinity College Dublin, Ireland.Escuela de Fonoaudiología, Facultad de Odontología y Ciencias de la Rehabilitación, Universidad San Sebastián, Chile.School of Psychological Sciences, Monash University, Australia.Department of Neuropsychology, Max Planck Institute for Human Cognitive and Brain Sciences, Germany.Institució Catalana de la Recerca i Estudis Avancats (ICREA), Spain.Department of Information and Communication Technologies, Universitat Pompeu Fabra, Spain.Centre for Eudaimonia and Human Flourishing, University of Oxford, United Kingdom.Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Portugal.Center for Music in the Brain, Department of Clinical Medicine, Aarhus University, Denmark.Department of Psychiatry, University of Oxford, United Kingdom. ![]()
0 Comments
Leave a Reply. |